Please could you evaluate the manuscript on the following questions according to the scale: 1 = poor, 2 = fair, 3 = good, 4 = excellent, NA = not applicable
?The scientific merit of the study
Contribution to current knowledge
?Does the abstract reflect the study and its findings
?Is the introduction of appropriate length and content
?Is the design appropriate and well executed
?Is Ethical Committee approval mentioned and/or informed consent
?Are the statistics appropriate
?Are the data presented clearly
?Do the conclusions fit the findings and integrate them into the current state of our knowledge
?Is the literature quoted adequate and appropriate
Overall recommendation (underline selection):
Accept without changes
Accept with minor changes (for evaluation by editor)
Accept with major changes (for evaluation by reviewer)

:Confidential comments to editor

:Comments to author
.In this section please add your detailed comments and evaluation of the manuscript